At a Palestinian cabinet meeting in Ramallah, Shtayyeh said he would hand over his resignation letter to President Mahmoud Abbas.
Shtayyeh said he decided to resign because of unrest in the West Bank and Jerusalem, which have been forcibly looted by Jewish extremists, and the ongoing war, crime, and famine in the Gaza Strip.
He also said that changes should be made to the way the Palestinian government operates in view of the current situation in the country and the challenges ahead. He said the Palestinian people must work together in view of the current situation in Gaza.
Shtayyeh's comments come amid increasing US pressure on President Abbas to begin work on a political framework for a Palestinian state.
Shtayyeh's resignation is intended to pave the way for the formation of a new Palestinian government. Nevertheless, political instability, the Israeli-Palestinian conflict and internal divisions in the Palestinian leadership have made major changes very unlikely in the near term.